Sentence examples for poses major obstacles from inspiring English sources
Anticancer drug resistance almost invariably emerges and poses major obstacles towards curative therapy of various human malignancies.
This often poses major obstacles for the efficient targeted delivery of SEPs, which is further aggravated by the high diversity of the tumor microenvironments (MacParland et al. 2017; Polo et al. 2017).
»The PCNA switch is important for flawless duplication of the genome, but paradoxically also for generating mutations.« Damaged DNA, e.g. damaged by UV light, poses major obstacles during replication.
So at this point it is not clear whether there will be a centre-left government, which would continue the negotiations, or a centre-right government, which would pose major obstacles for a continuation.
Second, climate change and disasters pose major obstacles in the fight against poverty.
The delays and funding shortfalls pose major obstacles to its existing plan, adopted in 2014, to complete an initial operating segment from Burbank to Merced by 2022.
The need to nurture kids' connection to nature is most acute in urban settings, where parental fears of strangers and traffic pose major obstacles to outdoor play.
Platform differences often pose major obstacles for extracting biologically relevant signals while effectively removing technical biases.
DOI: http://dx.doi.org/10.7554/eLife.00825.002 The molecular changes underlying human myeloid malignancies remain difficult to unravel, posing major obstacles to the development of effective countermeasures.
Inappropriate financial incentives, neglect of human factors, and the lack of a systematic approach to the science of health care delivery still pose major obstacles to better hospital care.
Although the US and European Union have enacted food and drug regulations for complementary and alternative medicine products that will reduce adverse events from poor drug quality, the lack of understanding of the potential harms of COTC self-medication and the inaccessibility of reliable information still pose major obstacles to drug safety.
