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The boundary between therapeutic and ergogenic (i.e. performance improving) use of pharmacological means is quite blurred and poses important problems to the controlling bodies of anti-doping practice and athletes' sports physicians [ 38].
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The septic, toxic and the immune complications of streptococcal infections pose important problems for the public health services.
Tropical or Mediterranean theileriosis is a tick-borne hemoprotozoan disease that poses important health problems in cattle.
Protective investments are extremely costly and risks are distributed in space and time, which poses important decision problems to the public sector decision makers.
The capacity of microorganisms, and especially P. Aeruginosa, to acquire new mechanisms of resistance under antibiotic selection pressure, poses important therapeutic problems and difficulties for the control of healthcare-associated infections.
Movements, instability and failures in open pit mines can pose important geotechnical problems, leading to major impacts on the safety of personnel and the mining operations.
Three-dimensional patterns of erosion and deposition associated with sediment waves pose important unsolved problems for the dynamics of alluvial forms and the effects on aquatic and riparian ecosystems.
Significant resistance of Gram-negative microorganisms to broad-spectrum antibiotics is noticed, posing important therapeutic problems.
Carbapenem-resistant strains that are also simultaneously resistant to various, non-beta-lactams antimicrobial agents pose important therapeutic problem, due to the limited number of efficacious drugs [ 5].
The fact that these first-generation signatures arguably are mere surrogates of proliferation poses some important problems for their use.
But, at the same time, it poses some important problems, the most significant being the difficulty of field rotation and the build-up of pathogens.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com