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South Sudan UN Humanitarian Coordinator Lise Grande says the lack of aid agencies working in the troubled state poses further difficulty.
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Then the O'Keeffe Museum dropped its suit, saying it did not want to pose further difficulties for the university.
High pressures deep underwater pose further difficulties, and may have contributed to the sinking of Russia's Kursk submarine in 2000, killing all on board.
The well known difficulty of taking into account edge effects during such measurements poses further questions as well as the effect of the density of occupation, and the seasonal variations due to clothing.
For teaching staff Brexit poses further challenges.
Noise pollution poses further risks.
Difficulties in measuring specific treatment inputs posed further constraints on our study.
A further difficulty comes in trying to compare datasets.
There is a still further difficulty.
Further difficulties are posed by missing data particularly the lack of self-reported drinking water consumption rates for many study participants.
In addition to the considerable technical difficulties posed in the production of vaccines against these complex organisms, further difficulties in securing acceptance for anti-helminth vaccine by regulatory authorities and by users, will be encountered.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com