Ron Shiffman, a former city planning commissioner, and Adam Friedman, executive director of the New York Industrial Retention Network, an advocacy group, warn that any effort to encourage commercial development in Long Island City or Brooklyn could also pose enormous problems for manufacturers.
Former UN humanitarian chief John Holmes has told HARDtalk proposals to establish humanitarian corridors in Syria sound easy to do, but in reality could "pose enormous problems".
Chronic arsenic exposure, for which the mechanisms of action are comparatively poorly understood, poses enormous human health problems for communities in developing countries that consume contaminated drinking water.
This approach, which has the virtue of evaluating new interventions in the process of trying to help individual patients, poses enormous scientific and practical problems.
This grisly calculus posed enormous cultural problems for early transplant advocates, as Kieran Healy, a sociologist at the University of Arizona and a contributor to the blog Crooked Timber, notes in "Last Best Gifts".
He has suggested he might continue to hold an ownership stake in his businesses, even if he steps away from day-to-day operations, but government watchdogs say that would still pose enormous ethical problems.
Inter-individual heterogeneity in drug response is a serious problem that affects the patient's wellbeing and poses enormous clinical and financial burdens on a societal level.
Inflammation genomics also poses enormous computational challenges.
SCD poses enormous financial burden on parents and households.
The diagnosis of the leishmaniases poses enormous challenges in Argentina.
