Sentence examples for poses a substantial challenge from inspiring English sources

Irrigation has led to significant groundwater depletion, which poses a substantial challenge to the sustainability of water resources in this basin.

We observe only a small number of apparently hazard-free regions, of the order of 5 to 20 metres in extent, the sampling of which poses a substantial challenge to mission success.

Membrane protein crystallization poses a substantial challenge, the reason of which is that transmembrane proteins remain functional and folded only when a proper microenvironment is supplied that allows interaction with a high and a low dielectric medium with the proteins' aqueous and membraneous moieties, respectively.

Cellular heterogeneity poses a substantial challenge to understanding tissue-level phenotypes and confounds conventional bulk analyses.

Andrade has looked extremely dangerous in recent fights and poses a substantial challenge for the champion who dethroned longtime queen Joanna Jedrzejczyk.

While this represents a significant milestone, using adherent culture for milligram-scale purification of the receptor monomer poses a substantial challenge.

Because of high periprocedural morbidity and mortality, patients with MPS pose a substantial challenge to the inexperienced medical care provider.

Wound infections, particularly of chronic wounds, pose a substantial challenge for designing antimicrobial dressings that are both effective against pathogens, and do not interfere with wound healing.

And the Alliance of Automobile Manufacturers, which represents a dozen of the biggest car and light-truck makers, recently wrote to the Trump transition team urging a reassessment of emissions rules that the group said posed a "substantial challenge" to the industry.

More than 1000 yrs of human intervention and the variety of land uses pose a substantial challenge when attempting to estimate sediment fluxes which is the first requirement to protect fragile wetlands.

Marine applications pose a substantial challenge in the robustness required for remote application, but recent developments in portable medical devices and receptor design suggest that these demands can now be realistically tackled.