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This situation poses a significant difficulty for our current transition kernels.
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The adoption of K coefficients posed a significant difficulty for local authorities.
Although this method can produce high-quality AAV vectors when used with multiple purification protocols, one critical limitation is the difficulty in scaling-up manufacturing, which poses a significant hurdle to the broad clinical utilization of AAV vectors.
Still, checkers poses a significant challenge.
Weather poses a significant challenge for drone traffic control.
Such a requirement poses a significant challenge for material growth.
Observing such signatures still poses a significant challenge.
Providing HAART during incarceration poses a significant challenge.
Modelling such socio-technical systems poses a significant challenge.
The legislation poses a significant risk to social media.
This issue has caused difficulties in implementing large-scale biomonitoring programs, particularly in relatively less-populated countries such as Canada, where remoteness poses a significant logistic challenge for sample collection, coupled with poor knowledge of the local fauna.
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