"poses a big challenge" is a perfectly valid and correct phrase that can be used in written English.
You can use it when you are describing a difficult obstacle that needs to be overcome. For example, "Providing a high-quality education to every student poses a big challenge."
So the breakdown of that correlation poses a big challenge for it.
However its low antigenicity and immunogenicity, which are related to its small size, poses a big challenge for vaccine development.
Highly viscous mucus poses a big challenge for the delivery of particulates carrying therapeutics to patients with cystic fibrosis.
Azimuthal angles and Doppler frequencies of radar targets usually suffer from estimation uncertainty in practice, which poses a big challenge in target detection.
Naturally occurring data have been growing in a huge volume size, which poses a big challenge to give them high-quality labels to learn a good model.
Worn dentition, often accompanied by occlusion changes such as reduced vertical dimension, poses a big challenge to both diagnosis and treatment.
Becker poses a bigger challenge than Gomez.
Getting students to take responsibility for their own learning poses a bigger challenge than improving students' computer and information skills.
From these results, light reception in the reactor is uneven and poses a bigger challenge due to the bias in gas bubble distribution.
More difficult to detect or monitor than its plutonium counterpart, a uranium program poses a bigger challenge to Western officials who fear North Korea could sell such technology abroad, as it has sold some of its reactor technology to Syria.
Lignin poses a bigger challenge to low enzyme dosage during the enzymatic hydrolysis process than hemicelluloses.
