The phrase "pose significant difficulty" is correct and usable in written English.
You can use this phrase when you need to reference a challenging situation or problem. For example, "Trying to solve the mathematical equation posed significant difficulty for the students."
It is well known in the multivariable control literature that ill-conditioned plants may pose significant difficulties in control design.
However, the number of simple sequence repeats (SSR; i.e., motifs between 2 and 25 nucleotides that are repeated in tandem) had a positive correlation with the number of INDELs (P<0.005), suggesting that genomes with highly repetitive sequences pose significant difficulties for sequencing and assembly (Table 4).
Therefore, the pain associated with the temporomandibular joint dysfunction may have a characteristic that is similar to the secondary neuralgia and may pose significant difficulties in differential diagnostics [ 4, 5, 8– 13, 14] 14].
Deposition of cBN (5∼20 μm) is of great technological importance but poses significant difficulty in terms of depositing it from vapor phase(s).
The variance heterogeneity poses significant difficulty in making statistical inferences for the estimated exposure response model (i.e., quantifying the uncertainty of the model estimates).
In the debate about the future of the Human Rights Act (HRA) the power of the home secretary to issue control orders poses significant difficulties for those who favour judicial and parliamentary restraint of executive power.
Modeling of thermal multiphase fluid flow in subsurface porous media poses significant difficulties for nonlinear solvers.
These structure complexities have posed significant difficulties for prediction methodology development.
However, major modifications to existing codes are often required to enable such simulations, posing significant difficulties in practice.
(For an argument for the claim that accommodating certain illusions poses significant difficulties for the disjunctivist, see Smith 2010).
We find that the non-linearity of the AMC poses significant difficulties in generating amplitude-modulated pulses at 200 GHz.
