Sentence examples for pose major obstacles from inspiring English sources

So at this point it is not clear whether there will be a centre-left government, which would continue the negotiations, or a centre-right government, which would pose major obstacles for a continuation.

Second, climate change and disasters pose major obstacles in the fight against poverty.

The delays and funding shortfalls pose major obstacles to its existing plan, adopted in 2014, to complete an initial operating segment from Burbank to Merced by 2022.

The need to nurture kids' connection to nature is most acute in urban settings, where parental fears of strangers and traffic pose major obstacles to outdoor play.

Platform differences often pose major obstacles for extracting biologically relevant signals while effectively removing technical biases.

Inappropriate financial incentives, neglect of human factors, and the lack of a systematic approach to the science of health care delivery still pose major obstacles to better hospital care.

Anticancer drug resistance almost invariably emerges and poses major obstacles towards curative therapy of various human malignancies.

This often poses major obstacles for the efficient targeted delivery of SEPs, which is further aggravated by the high diversity of the tumor microenvironments (MacParland et al. 2017; Polo et al. 2017).

DOI: http://dx.doi.org/10.7554/eLife.00825.002 The molecular changes underlying human myeloid malignancies remain difficult to unravel, posing major obstacles to the development of effective countermeasures.

»The PCNA switch is important for flawless duplication of the genome, but paradoxically also for generating mutations.« Damaged DNA, e.g. damaged by UV light, poses major obstacles during replication.

Both pose major safety issues.