Sentence examples for pose major difficulties from inspiring English sources

Currently, the treatment of PF continues to pose major difficulties.

These characteristics make the studies of CAR activation extremely challenging and pose major difficulties for evaluating drug-mediated CAR activation in vitro.

These features pose major difficulties in directly studying the gene content of dinoflagellates, and while some sequencing initiatives are underway, no completely sequenced genome is yet available.

The high variability of study methods and settings as well as the poor quality of data derived from the published literature pose major difficulties for analysis and the drawing of firm, generalizable conclusions based on study results.

The possibility of temperature gradients within the brain and the importance of damage to deep structures in causing severe neurodevelopmental impairment [ 46] and the lack of precise, non-invasive methods for measuring regional brain temperature pose major difficulties with selective head cooling.

Despite progress made in recent years in cancer chemotherapy, advanced solid tumors, including advanced carcinomas, sarcomas, melanoma, and glioblastomas, still pose major difficulties in their treatment, and the traditional therapeutic modalities alone have not provided satisfactory long-term clinical results [ 19, 20].

It raises serious concerns for all citizens, but also poses major difficulties for journalists and their sources, who can easily be exposed through these laws.

This is because creating a standardized plant medicine poses major difficulties -- especially in a case like marijuana where there are countless, widely varying strains and large numbers of chemical components about which little is yet known.

Human brucellosis has a serious medical impact worldwide, and its eradication poses major difficulties [ 5].

Delirium increases hospital costs and poses major difficulties for ward staff in feelings of helplessness, frustration and stress [ 16]; in time and resources to support those with delirium, and to manage distress caused to other patients by difficult behaviour exhibited by those suffering from it.

Time constraints in reconciling flexible mentoring arrangements with demands of other commitments posed major personal difficulties for lay-workers.