The phrase "pose major challenges" is correct and can be used in written English.
For example, you might write: "Climate change and other environmental concerns pose major challenges for future generations."
But a relatively tight budget and antiquated technology still pose major challenges for the S.E.C., outsiders say.
But a ground intervention in Yemen would pose major challenges, pitting the coalition against an insurgent movement backed by Iran with important redoubts in the country's north.
Both parties here fear that if frustrated voters approve the tax measures, they could pose major challenges for state and local governments in providing basic services.
For the millions of blind people living in the United States, paying for something in cash can pose major challenges because there is no difference between the size and shape of a $1 or $100 bill.
To be sure, Qaeda leaders and their top lieutenants use other secure electronic communications as well as old-fashioned means — like couriers, as Bin Laden did — that pose major challenges to American intelligence services.
The lack of physical stability of plasmid formulations however continues to pose major challenges.
In the past five years, however, a number of discoveries have posed major challenges to the Clovis model.
Of course this poses major challenges for the club game in this country, and France.
For years, golf was scarce in the Caribbean, where strict development rules and lack of fresh water posed major challenges.
"Deathly Hallows: Part 2," which analysts estimate cost about $200 million to make and $150 million to market, poses major challenges for movies set for release in its wake.
Automatic indexing and retrieval of digital data poses major challenges.
