The applicability of either approach hinges on the clinical question posed, the feasibility of studying it, and ethical considerations.
In such cases, the need for assessing intervention effectiveness across differing sets of substances by process or worksite poses further feasibility and cost challenges to using quantitative exposure assessment.
In developing the DOMUS trial, the authors have discussed several issues, which may raise criticism and pose challenges to feasibility and influence outcomes.
Moving forward, as we continue to expand the use of the electronic fingerprinting system, we may encounter issues in more rural settings where the substantially greater distance between recruitment areas and clinics and poorer mobile connectivity may pose challenges to implementation feasibility.
In such surveys, serum HIV testing poses problems of feasibility and requires informed consent, with the risk of non-participation and associated selection bias [ 3].
These issues are likely to occur when the EQ-5D-3L, ICECAP-O or ASCOT are administered in populations of older adults, and pose potential threats to the validity and feasibility of the measures.
However, the high amount of energy required for aeration of hydrolysates (which often have a high solids content), and the risk of infection at near neutral pH, pose a serious threat to the economic feasibility at an industrial scale.
Nonetheless, we expect that interpretation issues and positive responding pose a larger threat to the validity and feasibility of the measures.
Additionally, 6 policy makers and program implementers in the two countries indicated such a product would first need a small-scale pilot introduction to assess programmatic feasibility, safety, and acceptability, which could pose a potential obstacle to swift introduction.
The issues that occured most widely across a variety of respondents or that pose a serious threat to the validity or feasibility will be illustrated below (definitions of response issues are shown in Table 1).> -wrap-foot> Note.
