Sentence examples for pose a substantial problem from inspiring English sources

Second, the absence of non-trivial timing signatures for significant parts of both datasets may pose a substantial problem if data is used for detailed timing (or causal) analysis.

For many families a weekly programme in itself can pose a substantial problem of daily routine organisation, especially if this routine is already difficult to handle due to substance problems.

As these materials can vary widely in their texture, they can pose a substantial problem with respect to cleaning and disinfection, and therefore act as potential sources of MRSA and C. difficile transmission and dissemination.

From computer simulations of metabolic reaction networks we deduced a set important aspects to be considered when interpreting partial correlation coefficients in reaction systems: (a) Metabolites in equilibrium due to reversible reactions can readily be recovered, whereas irreversible reactions pose a substantial problem to association-based reconstruction attempts (in concordance with [ 6]).

Methyl mercury, the toxic form, even poses a substantial problem for the Arctic, she said, because it can accumulate in polar bears and seals.

One method would be to use real sequence data in existing samples, but detecting autozygosity in sequence data given current small samples, low pass coverage, and high error rate estimates (e.g., 1-3% in the thousand genomes data; [ 29]) poses a substantial problem in accurately estimating autozygosity.

However, with the availability of fast and highly accurate software for maximum likelihood (e.g., RAxML and GARLI [ 33]), such combined analyses should not pose a substantial computational problem.

Beyond violating our laws, visa overstays pose — and they really are a big problem — pose a substantial threat to national security.

Beyond violating our laws, visa overstays, pose -- and they really are a big problem, pose a substantial threat to national security.

Painful shoulders pose a substantial socioeconomic burden.

NCDs pose a substantial human and economic burden worldwide.