Sentence examples for pose a substantial challenge from inspiring English sources

Because of high periprocedural morbidity and mortality, patients with MPS pose a substantial challenge to the inexperienced medical care provider.

Wound infections, particularly of chronic wounds, pose a substantial challenge for designing antimicrobial dressings that are both effective against pathogens, and do not interfere with wound healing.

More than 1000 yrs of human intervention and the variety of land uses pose a substantial challenge when attempting to estimate sediment fluxes which is the first requirement to protect fragile wetlands.

Marine applications pose a substantial challenge in the robustness required for remote application, but recent developments in portable medical devices and receptor design suggest that these demands can now be realistically tackled.

If the new forecast of a decade of cooler temperatures in North America and Europe pans out, it will pose a substantial challenge to climate campaigners, politicians, and citizens: Can they produce meaningful action to limit the long-term warming that scientists still say is clearly ahead under a building greenhouse blanket even when it's cooling outside?

Neither of the two games is likely to pose a substantial challenge for the most beginner-level gamer, as both are designed to be played to their storyline climaxes.

Irrigation has led to significant groundwater depletion, which poses a substantial challenge to the sustainability of water resources in this basin.

And the Alliance of Automobile Manufacturers, which represents a dozen of the biggest car and light-truck makers, recently wrote to the Trump transition team urging a reassessment of emissions rules that the group said posed a "substantial challenge" to the industry.

We observe only a small number of apparently hazard-free regions, of the order of 5 to 20 metres in extent, the sampling of which poses a substantial challenge to mission success.

Membrane protein crystallization poses a substantial challenge, the reason of which is that transmembrane proteins remain functional and folded only when a proper microenvironment is supplied that allows interaction with a high and a low dielectric medium with the proteins' aqueous and membraneous moieties, respectively.

Cellular heterogeneity poses a substantial challenge to understanding tissue-level phenotypes and confounds conventional bulk analyses.