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But sex-determining genes pose a severe problem for the organization of a genome.
Livestock depredation has been one of the primary reasons for hunting wolves, and can pose a severe problem for wolf conservation: as well as causing economic losses, the threat of wolf predation causes great stress on livestock producers, and no foolproof solution of preventing such attacks short of exterminating wolves has been found.
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The outbreak of the Spanish Civil War in July 1936 posed a severe problem of conscience for Blum's Popular Front government: whether to send aid to the Spanish republic, the only other Popular Front regime in Europe.
The economic problems on Wall Street have posed a severe problem for Mr. McCain, moving the presidential debate to precisely the ground that favors Democrats, and Mr. Biden sought repeatedly during the debate to lay the problem at the doorstep of the Republican Party.
That posed a severe problem, though: Hot gas easily escapes the Milky Way's gravity, and resupplying the x-ray emitting reservoir would take large numbers of supernova explosions--many more than are thought to occur.
In the context of mobility in UDNs, the classical approach of user-initiated mobility management based on measurement reports poses a severe problem, provided the increased signaling and device measurement overhead.
In particular, homology annotation of small ncRNAs, with their short and often poorly conserved sequences poses a severe problem for large-scale annotation.
The aggregation to MSAs/CMSAs turns out to pose a severe empirical problem for a very simple reason: it is difficult to measure living wages at the MSA/CMSA level because of many instances in which MSAs or PMSAs within an MSA/CMSA adopt living wages at different times (and also at different levels, although the differences in timing are the more serious issue).
It is organisms whose evolution we can't control that pose a severe technological problem of aging for evolutionists.
The Rover investment -- and the difficulties in getting out of it -- posed such a severe problem for BMW that some questioned its own future as an independent producer of luxury cars.
Unlike the case in product units, the local minima problem does not pose itself as a severe problem in the model.
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