"pose a major obstacle" is a correct and usable phrase in written English.
It means to present or create a significant difficulty or challenge. Example: "The language barrier posed a major obstacle for the international team trying to complete the project."
Despite the development and subsequent improvement of new Mg-based alloys, their vulnerability to oxidation and corrosion continues to pose a major obstacle to their more generalized use.
The complex calculations involved – and in particular the activity-based costing procedure for computing the cost of managing the relationship – pose a major obstacle to widespread TCO implementation.
Transgene expression shut-down, attenuation and/or variability from integrated retroviral vectors pose a major obstacle to gene therapy trials involving hematopoietic cells.
The Federal Communications Commission, meanwhile, is not expected to pose a major obstacle to the deal and is awaiting the outcome of the F.T.C.'s review before it concludes its separate talks with the companies.
Major rebel forces -- some 7,000 fighters, according to Russian military estimates -- are now concentrated in the south, where the mountainous terrain will pose a major obstacle to any Russian advance.
The appeal, published online today in Nature, says that such a restriction would pose a major obstacle to bringing hES cell research to the clinic.
This poses a major obstacle for prosecutors and the agency's enforcers.
[C9.] Roadblock for Social Security Plan Disability insurance poses a major obstacle for President Bush's plan for personal accounts under the Social Security program.
Mr. Greenspan recently warned that the federal deficit, which is expected to surpass $400 billion this year, poses a major obstacle to long-term economic stability.
However, an unacceptably high operating voltage (4 20 V) has posed a major obstacle in the practical use of the NEM switch in low-power integrated circuits.
Altered signaling pathways in tumor cells help produce a suppressive tumor microenvironment enriched for inhibitory cells, posing a major obstacle for cancer immunity.
