However, overall effector numbers and their anticancer potencies remained restricted, which poses a limiting factor to clinical efficacy.
This is a very important factor to consider and typically gives problems for synthesis of larger oligosaccharides and definitely poses a limiting factor in polysaccharide synthesis.
Basic informatics principles, however, pose a limit on the applicability of such a description, since in general there exists no universal algorithm that could establish the equivalence of two Turing-complete language programs by formally analysing them [41, 42].
In regional comparative studies, where low replication will always pose a limit on our ability to make strong inferences, it is important to consider alternative explanatory mechanisms.
The computational effort required in practice might pose a limit to the size of problems that can be considered.
The lesions size did pose a limit to the number of biomarkers that could be assessed, limiting our study to four biomarkers with techniques available.
However, Lawesson׳s reagent also releases H2S spontaneously upon hydrolysis in aqueous solution, and it suffers from poor water solubility, which may pose a limit for its further applications.
On the other hand, the need for the system to unload the AZ cargo at places of physiological assembly (i.e., presynaptic AZ) might pose a limit to the 'wrapping' of AZ components and ask for a fine-tuned capture/dissociation balance.
Moreover, the lack of the multiplexing capability could pose a significant limiting factor for the real clinical potential.
This effect poses a limit to the conversion efficiency of the cell.
