Based on the validation methods described in the articles, the top portion of the validation hierarchy comprised studies that used a customized clinical method in a human for validation [10].
Large rearrangement analysis components of the 25-gene panel were validated on additional positive samples, along with the 100 samples used for the sequencing portion of the validation which did not contain large rearrangement mutations.
Taken together, these results describe the concluding portion of the LDT validation process and the use of mass spectrometry to detect a large number of complex reactions within a single run as well as its suitability as a platform appropriate for interrogation of scores to hundreds of targets.
Unfortunately, many models are developed yet only a limited portion of these undergo validation in various clinical settings.
In a cross-validation setting, fingerprints must be selected fresh from the training portion of that cross-validation fold.
Boroditsky, the Stanford professor leading the experimental validation portion of the project, and her student Paul Thibodeau found in previous studies that changing which metaphors are used to discuss a crime wave affects how people think it should be solved.
Correlations between factors 1 through 6 and other measures of psychological and physical functioning were calculated in the construct validation portion of this study.
In the validation portion of this work we demonstrated that searching for part information using a manual process is not a scalable or pragmatic method.
This lead to a portion of the regions within the validation cohort mapping adjacent to, rather than encompassing, SNPs showing 'conventional LOH'.
In one, the "relapse and disability" project as described in section II (example 3), findings could not be confirmed in the closed portion of the database – without the validation policy this would have lead to publication of a false-positive finding.
The gold standard for doing this is to set aside a portion of the data for this final validation step (the so-called test set validation).
