The push-out test was performed by applying a compressive load to the apical side of each slice by using a 0.7-mm-diameter cylindrical plunger attached to theupper portion of the testing machine.
Combing through data from the second trial, however, Lilly noticed that participants with mild Alzheimer's seemed to do better than controls in the cognitive portion of the testing, says Eric Siemers, a neurologist employed by Lilly. .
The Generalized Fluid System Simulation Program, an MSFC in-house general-purpose computer program for flow network analysis, was utilized to model and simulate the chill and fill portion of the testing.
The initial portion of the testing procedure requires the subject to sit quietly for two periods of 45 seconds each, while raw body volume is determined.
A measurement of thoracic gas volume (TGV) is obtained during the final portion of the testing protocol and is calculated as the functional residual capacity plus one-half of the tidal lung volume [ 4].
The final portion of the testing procedure requires that the subject perform several cycles of balanced tidal breathing through a tube followed by a "puffing" maneuver against an occluded valve.
