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Differences among genotypes within a neutral network represent cryptic genetic variation with no effect on the phenotype, and can be seen as the portion of sequence space that the individuals of a population can occupy without selective differences.
An engineered CuA protein was formed by replacing a portion of the amino acid sequence that contains three of the ligands to the native type I copper center of Pseudomonas aeruginosa azurin with the corresponding portion of sequence from the CuA center of cytochrome c oxidase from Paracoccus denitrificans [Proc. Natl. Acad. Sci. USA 93 19966) 461].
Disorder, which is encoded by a much wider portion of sequence space as compared to order, can indeed represent a strategy by which genes encoding overlapping reading frames can lessen evolutionary constraints imposed on their sequence by the overlap, allowing the encoded overlapping protein products to sample a wider sequence space without losing function.
Although large portion of sequence context was shared by mitochondrial genomes of CMS and male-fertile pepper lines, extensive genome rearrangements were detected.
We observed that a substantial portion of sequence tags perfectly mapped to other non-coding RNAs including snoRNA, siRNA, snRNAs, and tRNAs in Rfam database.
Regions of the 5' untranslated (5'UTS) portion of sequence accession x52772 (Rattus rattus Syt1) were cloned using RT-PCR with Rattus brain mRNA.
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In contrast, panels D and F show that a portion of sequences identified by SAM do not display visible differential expression.
Although a significant portion of sequences in each sample has been classified as eukaryotic or bacterial in origin, subsequent analysis showed that 825 November and 2352 June "bacterial" sequences match putative prophage elements in sequenced bacterial genomes, suggesting that some portions of these sequences may still be of viral origin.
Using the background corrected probe intensities allows one to eliminate a significant portion of sequence-dependent probe behaviors, including the increased mean and variance commonly observed in GC-rich probes.
However, only a small portion of sequences code for proteins [ 1– 5].
Currently, for a salmonid reference sequence, it appears that a substantial portion of sequencing should be done using Sanger technology.
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