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Most importantly, TGFβ1 rescued a significant portion of neurons from Aβ-induced death.
Such infection could be in previously uninfected sensory neurons since only a small portion of neurons harbour virus DNA in the latent state.
In fact, our theoretical results do not contradict to the experimental results by Meissner et al. (2005): For instance, the portion of neurons that were completely blocked by the stimulation might be located close enough to the stimulation electrode.
Herein, atrophy is considered a better marker for impaired functioning of brain regions than the deposits of insoluble proteins in plaques and tangles, since only a small portion of neurons contains tangles and the number of neurons that die, exceeds by far the number that contains tangles (Smith, 2002).
However, Bcl2-rescued group displayed a strong trend of mushroom spine enhancement in Grin1 f/f mice (Bcl2 vs GFP: p = 0.08, Figure 3Q), but not in WT mice (Bcl2 vs GFP: p = 0.5, Figure 3L), suggesting that NR1 KO GCs accounted for a portion of neurons rescued by Bcl2 and they had more mushroom spines than those dying of reasons other than genetic ablation of NMDARs.
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In FA, Zip14- and ferritin-reactive nerve cells are smaller than normal, and the central portions of neurons appear depleted.
This observation is supported by the postmortem analysis of the adult human midbrain, which reveals that colocalization of TH and GIRK2 occurs in all DAergic neurons of the SN, but also in a substantial portion of DAergic neurons of the VTA (Reyes et al., 2012), thus calling for a more stringent analysis of A9 subtype of stem cell-derived DA neurons.
Having media on in the background actually uses up a large portion of the neurons that could otherwise be employed on the task at hand.
A significant portion of AIP neurons were moderately selective for object shape, position, orientation, and size.
Rather only a small portion of the neurons was completely blocked.
However, a major portion of motor neurons with Golgi fragmentation did not show such inclusions.
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