Sentence examples for portion of factor from inspiring English sources
These data unambiguously demonstrate that this portion of factor Va heavy chain plays a role in controlling the catalytic efficiency of factor Xa within prothrombinase for prothrombin activation.
Altogether, these studies reveal that removal of the acidic COOH-terminal portion of factor Va heavy chain results in a cofactor molecule that is deficient in its clotting activity.
It is noteworthy that our data strongly suggest that deletion of a portion of factor Va to test its overall function within the cofactor molecule by functional assays alone, without analyzing the pathway to thrombin formation, does not represent optimal experimental conditions, required to obtain a definite answer.
Our data demonstrate that the COOH-terminal region of factor Va heavy chain is indeed crucial for coordinated prothrombin activation by prothrombinase because it regulates meizothrombin cleavage at Arg and suggest that this portion of factor Va is partially responsible for the enhanced procoagulant function of prothrombinase.
Recently, we have demonstrated that formation of meizothrombin by prothrombinase assembled with the plasma-derived cofactor is inhibited in the presence of low concentrations of an acidic region from the carboxyl-terminal portion of factor Va (represented by pentapeptide DYDYQ) (36).
Keeping all these findings in mind, we have recently established that the acidic COOH-terminal portion of factor Va heavy chain controls the rate of meizothrombin cleavage at Arg by factor Xa within prothrombinase, providing a productive interactive site of the cofactor with prothrombin, and thus contributes significantly to the enhanced function of prothrombinase (20, 21).
Inverted paralogous repeats are responsible for the inversion of a portion of the factor VIII gene that causes hemophilia [ 7].
Our data, put in the context of the literature, provide a logical explanation for these observations and demonstrate that the acidic COOH-terminal portion of the factor Va heavy chain controls the rate of α-thrombin generation by factor Xa within prothrombinase by controlling the rate of meizothrombin cleavage at Arg.
Judging from these figures, the reading score of NCT represents the largest portion of the factor.
Regardless of the certainty of causal association, the calculated attributable risk serves to quantify a portion of each factor present in MC.
Overall, the findings suggest that amino acid sequence DYDY from the COOH-terminal portion of the factor Va heavy chain regulates meizothrombin concentration (processing) during activation of prothrombin by prothrombinase.
