Sentence examples for pore voltage from inspiring English sources

The α1c subunit of the cardiac L-type Ca2+ channel, which contains the channel pore, voltage- and Ca2+-dependent gating structures, and drug binding sites, has been well studied in heterologous expression systems, but many aspects of L-type Ca2+ channel behavior in intact cardiomyocytes remain poorly characterized.

Mutations affecting ion channels can be used to investigate the function of the different domains of the ion channel protein (for example, formation of channel pore or voltage sensors).

Although the α1 subunit contains the channel pore, the voltage sensors, and most of the drug binding sites, the auxiliary subunits regulate all of these structures to increase channel opening, shift the voltage and time dependence of channel gating, and to increase drug affinity [5], [6].

Potassium channel crystal structures have shown a wide diversity in the juxtapositions between the pore and voltage sensor subdomains.

The α (conduction pore and voltage sensor-forming) subunit was expressed and purified with its β subunit, an aldo-keto reductase-like domain, attached to the cytoplasmic surface (Gulbis et al., 1999).

In addition, the spatial relationships between the pore and voltage sensor subdomains in NaChBac appear to be similar to those of the Shaker channel structure: the S3 and S4 helices of the NaChBac VS subdomain have been shown to be located adjacent to the pore subdomain, while the S1 and S2 helices are at the periphery of the channel.

(B ) The 16-exon kcnh4a gene (black box = exon, white box = UTR) encodes for a voltage-gated potassium channel that includes an N-terminal chain (black bar), pore and voltage-sensing domains (S1-6, grey bar), and the C-terminal chain (red bar).

These findings suggest that this conserved region is intimately involved in the formation of the ion conduction pore of voltage-activated potassium channels.

In order to obtain defect-free triangular arrays of pores, the voltage has to be adjusted so that the natural period of the porous alumina corresponds to the NIL-fabricated guiding pattern.

To ensure a homogenous nucleation of the curro-pores, a voltage pulse of 17 V for 1 s is applied that is followed by a constant anodic potential of 10 V for 36 min for the growth of the curro-pores.

A mitoK ATP) channel opener such as diazoxide led to a decrease in the inner membrane potential (ΔΨm) via modulation of Ca2+ influx and efflux through a ruthenium red-sensitive Ca2+ uniporter and a cyclosporin A-sensitive mitochondrial permeability transition pore, specific, voltage-dependent, nonselective high-conductance channels [20], [21].