Its efficacy in LGS was controversial according to one review [ 16] that included nine RCTs testing different drugs against placebo; no final analysis was possible because of heterogeneity of populations, therapies and outcomes.
Whilst this review focuses on process techniques for the production of single-cell type populations, therapies for certain disease types will necessitate transplantation of a functional tissue-like structure.
Another possibility is that the discrepancies are caused by differences in characteristics of the study population, therapy or outcome measurements (eg, duration of follow-up).
The regulatory system must be better aligned to make trials of personalized, small population therapies economically viable.
And in the polytrauma group, just as in the general Veterans Health Administration population, therapies for P.T.S.D. and T.B.I. accounted for 60 percent of total health care costs.
Nasal congestion, which represents a cardinal symptom of AR, appears to be difficult to treat and, especially for pediatric population, therapies that are both well tolerated and effective in relieving nasal congestion are needed.
In specific cases, such variability can profoundly impact the response of cell populations to therapy, in both antibiotic treatments in bacteria and chemotherapy in cancer.
Obtaining a better understanding of the evolution of resistant populations during therapy may enable the design of more effective therapeutic regimens which prevent or delay progression of disease due to resistance.
Defining HER2 amplification as a biomarker of trastuzumab responsiveness is integral to targeting appropriate populations for therapy.
Resistance of CSC populations to therapy was first reported in human acute myeloid leukaemia CD34+/CD38− stem cells (Costello et al, 2000).
