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As frequencies of loci can be significantly different among populations, stratification of population structure within the data is crucial to avoid spurious associations.
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Population stratification did not influence the outcome.
It also remains valid under population stratification.
However, the study is prone to population stratification bias.
Controls have to be carefully selected in other to avoid confounding by population stratification.
We also provide a method of controlling for confounding variables such as population stratification.
Methods were generally robust to population stratification, although some slightly less so than others.
Given that participants were drawn from genetic association studies they were Caucasian to control for population stratification.
Both of these results indicate negligible inflation of the genome-wide association signals caused by population stratification.
Next, population stratification was assessed.
There was no adjustment for population stratification (details see supplement).
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