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Using crossover and mutation, populations of models are created and compared with each other.
The gene sets represented in the populations of models selected using the GA-MLHD procedure have been analyzed using the Ingenuity Pathway Analysis (IPA) application (Palo Alto, http://www.ingenuity.com), a web based application that enables discovery, visualization, and exploration of biologically interaction networks.
3. Compare model accuracy on test data across generated populations of models.
Nevertheless, as reported earlier, this aspect needs to be investigated in more depth, for example, by exploiting the populations of models approach.
For each constraint combination above, GAMETES was used to generate a population of models of sizes 1,000, 10,000, and 100,000 yielding a total of 72 different populations of models.
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Recently, physical mutagenesis such as heavy ion irradiation (HII) has been used to generate mutant populations of model, crop and ornamental plant species [ 16- 18].
To the best of our knowledge, this method has only been implemented in populations of model organisms (Park 2011; Sved et al. 2013), but the increasing availability of linkage maps will facilitate Ne estimation in many species of conservation concern.
We were interested if purifying selection is associated with increasing recombination rate more frequently than positive selection, which is observed within populations of model organisms such as Drosophila melanogaster [ 38].
Genetic traits following a latitudinal gradient have been observed for several polymorphisms in humans as well as in natural populations of model organisms like Drosophila and Arabidopsis thaliana [ 9- 12].
Also, when designing an ensemble for an MDSS, the decision to diversify the model selection should be guided by the relationship between model instability and generalization error for the population of models under consideration.
Our approach required much lesser generations to provide a model with highest R2ext value as compared to the case where the DT did not initialize the population of models.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com