The following description focuses on the on-treatment population for simplicity.
The gonado-somatic index was assumed to be similar and constant for all mature individuals in the population for simplicity.
Because we did not calibrate IFN-gamma in our SDMM, we calculated the monocyte activation process using CD4+ T cell and CD8+ T cell populations instead of interferon-gamma (IFN-gamma) population for simplicity.
Please note that focal adhesions are likely to be composed of many actin filament populations, and for simplicity only the one undergoing vectorial actin polymerization and thus promoting stress fiber elongation is shown in the model.
In the following analyses, we used therefore a constant size population model for simplicity.
After exclusion of stromal cells, Ep-CAM/CD49f staining displayed three distinct epithelial cell populations designated here for simplicity as A,B and C: Ep-CAM-/low/CD49f + (A), Ep-CAMhigh/CD49f + (B), and Ep-CAMhigh/CD49fneg (C).
Both the single layer in the embryonic epidermis and the innermost layer, namely the basal layer, of the stratified epidermis are securely attached to a basement membrane, and are treated as identical populations in this study for simplicity.
The proportion of migrant alleles arriving and leaving each population was further controlled by simulated population specific FST values which, for simplicity, were set equal in each population.
Furthermore, histograms and normality tests suggest that all freshwater pond samples can be treated as a single population, which we do for simplicity.
This kind of initial population is considered only for simplicity in simulations.
F can differ for populations 1 and 2, but for simplicity, we set F to the same value for both populations.
