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Because our Norse population surrogate was based on limited published Norwegian data, we used only a subset of the autosomal data (HLA-A, -B, -C, -DQB1, MC1R and rs7853989) for the admixture analysis.
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Immunofluorescence microscopy and flow cytometry were used to detect the GFP-negative population as surrogate readouts for delivery (Fig. 6e, f, respectively).
DNA of northern white rhino — of which only two remain — mixed with that of close subspecies in a bid towards growing population using surrogates.
A better understanding of the remodeling response of vein grafts in humans is required to design effective molecular therapies and to define the appropriate target populations and surrogate markers for future clinical trials.
As direct measurements of individual sunlight exposure were not possible, we employed two population-level surrogate measures that are associated with sunlight.
We exposed embryos from these two populations to surrogate model PAHs and analyzed changes in gene expression, morphology, and cardiac physiology in order to better understand sensitivity and adaptive resistance mechanisms mediating PAH exposure during development.
As the ancestral populations become more similar or the surrogate populations become more different from the true ancestral populations, the localized admixture signals become increasingly noisy.
Therefore, using few contemporary Caucasus populations as surrogates may capture only certain shades of the Khazarian genetic spectrum.
The bootstrap method is based on the use of the original data to generate a surrogate population of samples, where the correlations contained in the original one are removed/destroyed.
Aspects of cognition may be the most important endophenotypes for psychiatric conditions such as schizophrenia, leading many researchers to pursue large-scale studies on the genetic contributors of cognitive performance in the normal population as a surrogate for aspects of liability to disease.
Moreover, such inference can still be performed (albeit with reduced power) when data are available from only the admixed population and one surrogate ancestral population, whereas all previous techniques require at least two such reference populations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com