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The participants in this analysis were recruited in August and September 2009 using random sampling from the source population supplemented by invitations to participants from the previous season.
Another study, a post-hoc analysis of two different studies, found lower responses in the population supplemented with folic acid [ 24].
Nine QTL regions were used in the BC2 population, supplemented with 6 QTL regions that, on their own, were only significant in the BC1, in order to increase the number of loci in the epistasis analysis.
Lyneham and Rapee, 27 for example, in a study of the treatment of childhood anxiety in a rural Australian population, supplemented a workbook for parents with nine scheduled weekly phone calls or emails.
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In the rugged mountains of the north and west, the farms are small, and much of the population supplements its earnings by migration to Great Britain.
Using 17 microsatellites, we genotyped pre- and post-stocking samples from four Atlantic salmon populations supplemented with non-native fish to estimate genetic admixture.
Further, genetic diversity in steelhead populations supplemented with native broodstock remained unchanged after 20 years (Heggenes et al. 2006) and 58 years (Gow et al. 2011).
For example, relaxed selection pressure presumably selected for smaller egg size in a hatchery population of chinook salmon (Oncorhynchus tshawytscha), and populations supplemented with large numbers of fish from this hatchery showed a reduction in egg size that could be detrimental to fitness (Heath et al. 2003).
Uncontrolled trials formed the basis of approval for 34% (22/65) of expanded population supplements, and nine (14%) of these supplemental approvals had no clinical efficacy trials.
Ten supplemental indications were approved with no clinical efficacy trials (9 expanded population supplements and 1 modified indication supplement).
Two supplemental indications and one original indication were supported by historical controlled trials; in addition, 10 supplemental indications were approved with no clinical efficacy trials (9 expanded population supplements and 1 modified indication supplement).
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