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CD107a was up-regulated in the PDC population subsequent to stimulation with HNSCC, indicating cytokine secretion.
As NOTCH-1 has been shown to regulate PDC versus T cell lineage decision through control of GATA-3 and SPI-B [18] we analysed the mRNA levels of the PDC population subsequent to stimulation.
Furthermore the data comprise a strong indication for the up-regulation of the recombined D-J-β chain in the PDC population subsequent to stimulation with HNSCC cell-lines (Figure 4).
Selective MDM uptake of different T cell subsets was quantified by expressing the proportion of each subset in the T cell culture prior to uptake, and within the MDM population subsequent to uptake, as an uptake index.
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Binding CB1R suppressed secondary population afterdischarges subsequent to antidromic activation of the granule cells.
While successful clones expand in the population, subsequent mutations continue to produce sequence and fitness variation; that is, new clones originate nested within previous clones (Park and Krug 2007; Desai and Fisher 2007).
These two observations taken together suggest that, on average, LSDs are relatively young compared with population duplicates, and subsequent to their generation, they display a burst of evolutionary change.
Although we set out to recruit a cognitively healthy population, subsequent consideration of information from a wide variety of sources revealed that a very small number of subjects were likely to have been experiencing dementia at baseline.
This paper describes the 1 year prevalence of these disorders in this population; subsequent papers will report headache-attributed burden.
Population growth and migrations subsequent to this ancient episode of selection would explain the present day distribution of this allele across a wide variety of climactic conditions [19], notably in the Americas.
For 8 species samples were obtained from zoo animals that were killed for population management reasons, or died subsequent to trauma.
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