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More specifically, failure to recognise and correct for erroneous estimates of α is found to produce substantial overestimates of the combined population significance which worsen with increasing target multiplicity.
Coherence magnitude was averaged across all cells in a given population; significance limits were assigned to these averaged coherence spectra as described in Evans & Baker (2003).
For each marker, Chi-square analysis was performed to test goodness-of-fit to expected 1 2 1 segregation ratio for the F2 population and 1 1 ratio for the RIL population (significance declared at P < 0.01).
Power analysis was conducted with the following parameters: allele frequency 0.49, frequency of endometriosis associated infertility 0.03 in population, significance level 0.05, two-sided We observed significantly increased FCRL3 transcript levels in the CD19+ B cells from carriers of the FCRL3 −169 C gene variant as compared with carriers of the FCRL3 −169 TT genotype in fertile women.
Furthermore, slopes for both the Eff and Ineff morphs are significantly different from zero in the early time window (sign test, P < 0.0001, population significance), whereas in the late time window, only slopes for the Ineff morphs are significantly greater than 0 (sign test, P < 0.0001).
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Likewise, BARC1.01Gm01_52253980 and adjacent markers have pan-trait, pan-population significance (Table 3 and Figure S1).
Given the clear differences in size among populations, significance of the statistics was tested using the isolation models with unequal population sizes as null model.
In the overall population, the significance of changes in the quantitative variables over time was determined with the one-way ANOVA test for repeated measures; paired comparisons between 2 consecutive timepoints were then analyzed with the Wilcoxon sum of ranks test.
The effects of Race and Population reached significance.
No effect involving Population reached significance; it was therefore dropped.
The effects of Sex, Race, and Population reached significance.
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