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The field population screens offer some clues about where additional research should be focused.
Commonly used population screens for psychological distress include the General Health Questionnaire (GHQ) family of instruments.
Large population screens also suggest that only a minority of HFE C282Y homozygotes develop clinical signs and symptoms of iron overload [ 20- 22].
Nevertheless these large-scale population screens often overlook the tremendous variation in the mitochondrial genome (mtDNA) and its involvement in complex disorders.
The practitioners of large-scale RNA interference screens have followed the yeast playbook closely by, for example, barcoding interfering RNAs (or leveraging the hairpins of short hairpin RNAs as barcodes) and using PCR amplified barcodes from large population screens to deduce strain or cell line abundance (Ketela et al. 2011).
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These estimates pertain essentially to increased diagnostic use rather than population screening.
H pylori population screening seems attractive.
No studies examined general population screening.
Reconciling Opportunistic and Population Screening in Clinical Genomics.
Three types of population screening programs are in operation.
There were ≥ 70% correct responses about at-risk population, associated abnormalities, and population screening.
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