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The design of randomized controlled clinical studies can greatly benefit from iterative assessments of population representativeness of eligibility criteria.
To develop a multivariate method for quantifying the population representativeness across related clinical studies and a computational method for identifying and characterizing underrepresented subgroups in clinical studies.
We propose a multi-trait metric - GIST 2.0 that can compute the a priori generalizability based on the population representativeness of a clinical study by explicitly modeling the dependencies among all eligibility criteria.
Clustered sampling is an alternative sampling approach commonly used to reduce the recruitment effort and gather data from subjects, without reducing the whole population representativeness.
Controls were recruited from various sources to parallel population representativeness.
The clear disadvantage of this strategy is a sacrifice of population representativeness.
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The strengths of this study are its large size, population-representativeness, and completeness.
Overall, estimates of time use between the two different approaches were comparable, but it was recommended that survey weights were applied to the Time-Use Survey (as done here) in order to increase population-representativeness (Lader et al., 2006).
The sample size of 750 adult women age 20-400) years was based on geographic area and population size representativeness, excluding the Milan region which had already been represented in the magazine survey.
(d) For studies implementing the intervention in one community group but measuring effects at the population level, representativeness (under selection bias) was marked as 'somewhat likely' aGiven the heterogeneity of individually reported designs, they were classified according to the instruments' typology.
Our study includes all PHC organizations in two large regions, a sample of the population with representativeness at the Local Network level and nominal linkage with the regular source of care.
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