"We analyzed six genes and found one gene that confirms, in this population, a predisposition to the birth of twins," Dr. Matte said.
A subsequent FDG-PET study, in a heterogeneous extracranial cancer population with predisposition to onset of depression, showed decreased glucose metabolism in the right medial frontal gyrus but increased metabolism in the right anterior and posterior cingulate gyri, left subcallosal gyrus, and left caudate nucleus [46].
Rather than monogenic mutations that are rare and occur in limited populations, genetic predisposition to gallstone susceptibility in general populations arises from polymorphisms in multiple genes, each making a small contribution to overall risk.
HIV/AIDS, tuberculosis and malaria are diseases that demand consideration of populations' underlying predisposition to disease in the forms of socioeconomic inequality and abject poverty.
We experimentally manipulated the potent anti-inflammatory cytokine IL-10 [ 25, 35], an immune signaling molecule that is thought to be under balancing selection in human populations: genetic predisposition to strong IL-10 responses is beneficial in terms of avoiding excessive inflammation but costly in terms of reduced ability of hosts to control parasite replication [ 36].
Again, this is similar to aortic disease in the human population where genetic predisposition can impact upon the penetrance of disease phenotypes.
Indeed, it appears that there is increasing evidence that mild reductions in DNA repair capacity, assumed to be the consequence of common genetic variation in the human population, affect cancer predisposition (Mohrenweiser et al, 2003), and, by inference, possibly modulate the response to radiation treatment as well.
Importantly, these discrepancies were shown to persist even after socioeconomic differences were considered, leading many to hypothesize that a population-based genetic predisposition, likely related to African ancestry, is responsible for the observed elevated risk for ESKD among African Americans.
It has surely been comforting to anyone concerned with the preservation of social order to think that, a few exceptions aside, half the population has a natural predisposition toward sexual stability.
There is some evidence that the risk of HF in the general population depends on genetic predisposition, necessarily characterised by a very complex architecture.
