Exact(7)
We used the breeding population pedigree information (relationships between first and second generation) to detect possible Mendelian Inconsistencies (MIs) between parents and offspring using the PedCheck software [37].
This approach capitalizes on the fact that different family structures differ in their power to detect linkage [24] by successively considering the use of different splittings of the population pedigree.
The full MAGIC population pedigree is available from http://www.niab.com/magic/.
The genotypes of the last generation were gene-dropped into the sorted real population pedigree.
Final marker order and map distances were computed from the complete reference population pedigree and genotype data.
RAPD and arbitrarily primed polymerase chain reaction technique (AP-PCR) are powerful tools for gene mapping, population, pedigree analysis, phylogenetic studies, and strain identification [ 47].
Similar(53)
All population pedigrees included nuclear families with 1-2 offspring in a half-sib family structure.
In studies of natural populations, pedigree construction is an important component in determining breeding structure and estimation of genetic parameters (Blouin 2003; Pemberton 2008).
ROADTRIPS uses a covariance matrix estimated from genome-screen data to correct for unknown population and pedigree structure while maintaining high power by taking advantage of known pedigree information when it is available.
Thornton, T. & McPeek, M.S. ROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure.
It is well known that failure to properly account for population or pedigree structure can lead to spurious association as well as reduced power.
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