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One of the major causes of drug resistance is a large, lingering population of pathogens which happens in patients with chronic infections," Dr Lewis said.
However, because infection and proliferation of E. coli occurs primarily in the lower intestine, there is interest in "by-passing" the rumen, thereby, delivering chlorate directly to the largest population of pathogens.
We model the population of pathogens as a metapopulation composed of subpopulations (infected hosts), where pathogens replicate and mutate.
In chemotherapy, the desired outcome is eradication of a population of pathogens or cancerous cells.
A major challenge posed by studying diverse clinical strains is that the sampled population of pathogens may contain population structure related to the shared ancestry of the strains.
However time-course samples are often difficult to obtain, particularly in clinical settings, and may not always be generalizable to the larger population of pathogens [ 46].
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Using an agent-based computational model of an evolving population of pathogen cells, we test this hypothesis and find support for it.
When pathogens were treated with a drug targeting a shared rather than a cell-intrinsic molecule, the reduced evolution of drug resistance resulted in a smaller final population of pathogen cells (Fig. 4).
The evolutionary struggles between host adaptive immune responses and populations of pathogens are now open to greater scrutiny, elucidation of the underlying reasons for successful or failed immunity, and potential predictive modeling, than ever before.
We're going to see changes in populations of pathogens". While traditional responses might be to add more pesticides or deforest more land for agriculture to produce greater crop yields, CRISPR may be able to quickly create disease-resistant seeds for farmers.
Since the population size of the normal microbiota is large, multiple and different resistant variants can develop, which increases the risk for spread to populations of pathogens.
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CEO of Professional Science Editing for Scientists @ prosciediting.com