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Each one generated a large population of memory T cells specific to the viral or tumor peptide.
Inside the patients, the T-cells modified by the researchers multiplied to 1,000 to 10,000 times the number infused, wiped out the cancer and then gradually diminished, leaving a population of "memory" cells that can quickly proliferate again if needed.
In the above experiments, naïve cells were defined as CD4+ CD45RO− CD62L+, which excludes the CD45RA+ population of memory CD4+ T cells.
Once the infection is resolved, 90 95% of activated effector CD8 T cells die through apoptosis, while the remainder form a long-lived population of memory cells.
These data strongly suggest that lung contains a population of memory T cells that can respond rapidly to challenges from the environment.
In order to verify whether CD27− B-cells represent a population of memory B-cells, we studied the SHM pattern in the Ig VH region of Cγ transcripts of CD27−IgD+ B-cells.
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It is often assumed that immunological memory depends on populations of memory CD4 T cells that are long-lived.
Immune responses to different viruses can result in distinct populations of memory T cells that differ not only in the spectrum of their antigen receptor sequences but also surface phenotype and effector function (reviewed in [27]).
There were two reasons for this: the first was because the results of the main study we were attempting to qualitatively reproduce did not explicitly measure populations of memory T cells [5].
Therefore, we also stained for different populations of memory CD4+ T cells using these markers.
Additionally, the expansion of CMV-specific memory T cells can overwhelm immunological niches, leading to the loss of both naïve T cells and smaller populations of memory T cells [ 84].
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