Sentence examples for population of islets from inspiring English sources

Our intent was to enhance our chances of detecting transferred cells around the limited population of islets accessible by two-photon microscopy through the acute and synchronized nature of autoimmune diabetes observed in this model.

A more quantitative assessment of the beta cell mass would need to account for both changes in beta cell numbers within insulin-positive islets and changes in the distribution of insulin content within the population of islets.

β-galactosidase activity was detected as a surrogate for GPR120 expression exclusively in a small population of islet endocrine cells located peripherally within the islet mantle.

The clocks of dispersed beta and non-beta cells seem to be well synchronised among themselves, and they exhibit oscillations with a similar period length to that observed in a mixed population of islet cells.> We provide for the first time convincing evidence for cell-autonomous clocks displayed in cultured human islets.

Translation of this approach into man will require methods to generate large populations of islet-specific Tregs which, to date, has proved to be a major hurdle.

Immunohistochemical staining of pancreatic sections from 12 week old Idd9 congenic and NOD mice confirmed that a sub-population of islet β cells in both strains express TNFR2 protein, whereas no staining occurred using the secondary antibody alone, or in islets from B6.TNFR2KO mice.

However, when assessed in a defined population of smaller islets (<120 μmol/l) from older mice (12 15 weeks), we observed a significant difference in islet cell survival with a survival advantage of ZnT8−/− mouse islets after 24 h (p < 0.001) or 48 h of hypoxia exposure (p < 0.01) (Fig.  6i).

Of the analysed single islets, 76% (13 out of 17) were oscillating for 3 days of recording, with an oscillation period of 23.99 ± 1.20 h, closely matching the results obtained in the population of human islets (Fig.  1b).

The delta cells typically comprise 5 10% of the endocrine population of mouse islets and they synthesise and secrete somatostatin-14, an isoform that accounts for approximately 5% of circulating somatostatin [ 28, 29].

Tetra-immunostaining enabled precise population of four islet endocrine cells on the same sections in each case.

In contrast to adulthood, during the fetal and early childhood stages of human development ghrelin cells are much more numerous and comprise approximately 10% of the population of pancreatic islet cells [ 17].