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Thus, a combined population of intermediate and DEEP chondrocytes might be more suitable for the tissue engineering of articular cartilage.
As discussed above, Foxg1 haploinsufficiency has been shown to decrease the population of intermediate progenitor cells [52].
Instead, we computationally phenotype a large population of "intermediate" genomes, each containing a random sample of alleles from a set of polymorphisms identified from a natural population.
Since the phenotype we examined was strictly computational, we could easily phenotype an arbitrarily large synthetic population of intermediate genomes to understand how sequence polymorphisms produce variable gene predictions.
Cells containing two replisome foci (49%56%%) were predominant in the cell population of intermediate length, precisely those expected to be undergoing DNA replication (S phase).
Similar to the decrease of dividing radial neural progenitors, the population of intermediate neural progenitors marked with Tbr2 is markedly downregulated in the absence of mTOR.
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These results indicate different free-energy landscapes for folding of small oligomeric proteins compared to monomeric proteins, which typically avoid the transient population of intermediates.
Both modules fold via two-state kinetics [44] (it should be mentioned that the use of a more strong denaturant reveals the population of intermediates in the faster folding of the 10th module [45]), and the relatively slow folding of the ninth module is not due to the occurrence of a slowly folding on-pathway intermediate [46].
As overall death rates were low in this population of intermediate- and low-risk patients (5%, range 1% to 13.5%), the NLR would be a better assessment of its usefulness.
Furthermore, as the findings of the present study are not based on a random sample of patients, it is unknown to what extent these results are representative of the overall population of intermediate- and high-risk patients with NMIBC.
Second, the observation that only a handful of the original list [ 1] of two-state proteins remain for which intermediates have not been detected poses questions about whether the population of intermediates is a pre-requisite for rapid and efficient folding, or results from the stochastic nature of the evolution of structure during folding reactions.
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