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This is the consequence of the several choices that researchers have to make in designing a trial regarding population, measurement tools and interventions.
Standard population measurement techniques describe average behavior and are insufficient to investigate variability among cells [8].
While Benton et al. demonstrated that ectopic olfactory receptors are functional by population measurement using calcium imaging on the antennal lobe, we used single-sensillum recordings that gives a greater temporal resolution.
Two authors (EGK, ZY) extracted information from each article selected for inclusion including the number of cases and non-cases, study design and population, measurement of WBC and diagnosis of T2D, effect estimate and 95% confidence intervals for associations between WBC, neutrophil/granulocyte, lymphocyte and monocyte count and T2D risk.
For particles larger than 1 μm, often present in relatively low concentrations, individual particle rather than composite population measurement techniques are applicable.
Different findings of effect modification by GSTM1 variation across studies may reflect differences of exposure, outcome and population, measurement errors in exposure or phenotype, and by chance.
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In epidemiology and population measurements, however, a truly gold standard measure can rarely be used for validation studies, and the use of imperfect or 'alloyed' gold standards risks introducing more bias than they are correcting [ 17].
Modern and wild population measurements courtesy of Fuller.
Therefore, the proposed in vitro method bridged the gap between population measurements and quantitative single-cell analysis.
Since the existing experimental data on population measurements only yield average values, this may help explain why ZEB1 mRNA appears to be bimodally distributed (Zhang et al., 2014).
By integrating these results from single particle and population measurements, an energy landscape of P22 maturation from procapsid through expanded shell to wiffle ball emerged, highlighting the role of metastable structures and the thermodynamics guiding maturation.
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