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β1 integrin is highly expressed by the developing hair follicle stem cell population, expression extending distally from the bulge to the HF bulb.
The importance of cell population expression profiles is in their potential to identify new rational targets for pharmacotherapeutic interventions in progressive neurodegenerative disorders such as AD.
Possible explanations for this ambiguous clustering may be variation in lifetime environmental influences (e.g. life style or the conditions under which the patients had died) and genomic-background effects for individual patients, which would contribute to population expression variation (i.e. noise).
This observation led us to examine HER2 population expression by both anti-ECD and anti-C-terminal antibodies on the 14 day whole tissue sections using quantitative immunofluorescence.
Xenografts are characterised by the lack of human stroma providing a good model to study the specificity of the tumour cell population expression.
Therefore, this variability should be taken into account in the future by implementing corresponding population expression data in the dynamic analysis.
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In our study, 60% (6 out of 10) of the genes showing inter-population expression differences associate with copy number changes, which reinforce the view that these variants are indeed important modulators of expression.
Finally, these methods are applicable to many studies of the characteristics of defined neuronal populations, expression analyses, generating defined mixtures of cell types to test disease models for non-cell-autonomous phenotypes, and for drug testing and development.
Our microarray survey identified over 500 genes showing low within-population expression polymorphism, but high between-population expression divergence in female D. melanogaster from Europe and Africa.
A good study has demonstrated that the within-population expression variability of genes can influence the propensity of their differential expression levels between populations [ 42].
In this case, the between-population expression difference appears to be specific to the Malpighian tubules, where CG9509 shows highly enriched expression [ 51].
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