Whilst it can be argued that it is likely that the diary population is representative of the larger household population completing the CATI only, a further question is whether the population completing the CATI are representative of the whole population of Rouse Hill dual reticulation households, including those that did not complete the CATI.
34 Since persons with IEI-EMF typically report more symptoms than the general population, 35 a symptom diary is more suitable to obtain a valid estimate than asking to report the usual or average number of symptoms retrospectively.
In addition, the EE and DE diary ITT populations were analyzed separately.
A two-stage gate-keeping multiple-testing procedure 16 was used for comparisons between ESL treatment LS means and placebo LS means for the ITT and DE diary ITT populations in the primary analysis.
In this study, we assessed the acceptability of a DHD, compared with a traditional paper diary, in a population of MOH inpatients recruited while in hospital undergoing detoxification.
There were no important differences in the study population demographics or time-activity diary data for the sampling days of all participants (n = 700) and those included in the analysis (n = 383).
Data were collected from a random subsample of 725 women (7.7% of the trial population) using structured interviews, coital diaries, in-depth interviews, counting returned gel applicators, focus group discussions, and ethnography.
A study investigating a chronic pain population showed that the sleep diaries and actigraphs provided similar estimates of total sleep time, time awake after sleep onset and sleep efficiency, but differed in sleep latency and nocturnal awakenings [ 8].
Technology advances and the increased prevalence of electronic device ownership around the world [ 1] means that electronic versions of COA (eCOA) can be used in a wide range of areas including clinical trials, routine health care and clinical settings, and also in the general population as, for example, health diaries that enable the assessment of change in health over time.
It is therefore possible that the household population completing both the CATI and diary may have differed in some way from those that completed the CATI only.
