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In population pharmacokinetic studies, the precision of parameter estimates is dependent on the population design.
Figure 2 Backcross population design to distinguish female meiotic drive from male-specific sources of distortion, and to distinguish gametic and zygotic differential selection mechanisms.
Furthermore, this article discusses potential breeding schemes for GS, genotyping considerations, and methods for effective training population design.
It was demonstrated that the initial population design influenced the number of optima found during a genetic algorithm optimization procedure.
It discusses sources of variability, including the goal of the CAD system, learning methodology, study population, design, outcome measures, inclusion of radiologists, and study quality.
In the era of next-generation sequencing, there has arisen an urgent need for proper population design, advanced statistical strategies, and precision phenotyping to fully exploit high-throughput genotyping.
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Further algebraic results pertaining to d-point D-optimal population designs where d≥3 and to V-optimal population designs proved elusive.
Two cases studies are investigated: single population designs, and stratified population designs, where different kinds of lights are replaced in the same retrofit study.
Evaluation of population designs by simulation is time consuming and is not suited for design optimization.
The analyses were conducted on an experimental mice population designed to reduce environmental variability for LS.
My main contribution in pharmacometrics is certainly all the work I perform with my team on optimal population designs.
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