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Recently, the results of a universal, population based trial to prevent child maltreatment have been published by Prinz, Sanders, Shapiro, Whitaker, and Lutzker [ 24].
For instance, the number of families that received the Triple P intervention in the population based trial described by Prinz and colleagues [ 36] is unclear, making it impossible to calculate an effect size.
15 The numbers of randomised participants ranged from 55 736 in the Norwegian study to 170 432 in the UK trial, but even considerably larger numbers had undergone prescreening for their interest to participate in the UK and Italian trial, whereas the Norwegian study was the only true population based trial.
In 1997-2000 women aged 32-38 who took part in organised cervical screening in five regions of Sweden (Gothenburg, Malmö, Stockholm, Umeå, and Uppsala) were invited to participate in a randomised population based trial of primary HPV screening with general primer GP5+/6+ polymerase chain reaction.
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13 In colorectal cancer some information can be gleaned from the previous population based trials.
Following the Society for Research on Nicotine & Tobacco recommendations, biochemical verification of smoking abstinence has not been performed because of the low misreporting rates in large-scale, population based trials that have limited face-to-face contact with study staff [ 36].
In screening for colorectal cancer comparatively little is known about the relative effects of prevalence and incidence screening, as the only information that is available from long term screening programmes comes from population based trials of screening using the guaiac faecal occult blood test, 2 3 4 5 6 7 where the emphasis was on the effect of the programmes on disease specific mortality.
The objective of this study was to compare current drug use related to co-morbidity between individuals with a recent diagnosis of AD and a cognitively healthy control group in a population based clinical trial in Northern Norway.
Participants 247 831 participants in a prospective community intervention project in China (1993-95) to prevent neural tube defects with 400 μg/day folic acid supplementation and 1194 participants in a population based randomized trial (2003-05) to evaluate the effect of folic acid supplementation on blood folate concentration among Chinese women of reproductive age.
In the Netherlands, population based screening trials by gFOBT, iFOBT and FS have already been performed.
Population based case control trials display a cumulative incidence of VTE of up to six-fold in cancer patients [ 11].
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