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Strengths of this study include population based sampling, a randomized controlled design, and high participation and follow-up rates, all of which increase confidence in the findings.
It was thus not a random, population based sampling frame; recruitment depended upon GPs' agreement to assist.
As nearly all people in the United Kingdom are registered with general practitioners through the National Health Service, the age-sex registers form a population based sampling frame.
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Participants were recruited into the study between June 2012 and July 2015 using both convenience- and a quasi-population- based sampling.
First, they are based on the analysis of contemporary population-based sampling frames, a relative rarity in this field of study [ 1].
Prior to this study, 149 case probands (4%) who had been recruited into the BCFR via population-based sampling had been found to carry a BRCA1 mutation [ 17].
Due to these features, population-based sampling methods can be applied to a wide spectrum of problems.
Population-based sampling methods, such as evolutionary algorithms, are generally applied to solve large optimization problems with rugged energy landscapes.
Population-based sampling was used to recruit 62 of the participants, which allows for estimations of prevalence.
United Kingdom 720 128 90 Modified population-based sampling through 12 GP practices in 11 areas (in UK, virtually all residents are registered with local GP).
UK 720 Modified population-based sampling attempted through 12 GP practices in 11 areas (in UK, virtually all residents are registered with local GP).
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