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In the alendronate trial performed in a LTC population, adverse events were not suffered to a greater extent in the treatment group compared to controls [35], albeit relatively small sample size may have been a limiting factor in detecting this outcome.
Briefly, drugs with the potential to cause IMDILI were identified from population adverse drug reaction (ADR) data.
Due to polypharmacy in the elderly population, adverse drug reactions are an important cause of morbidity and mortality.
We chose to focus on immune-mediated DILI since these reactions have defined clinical characteristics that allow us to identify cases from population adverse drug event data.
Among patients in the safety population, adverse events were reported by 952/2643 (36.0%) patients; 327 (12.4%) patients had adverse events which led to discontinued study participation.
High percentages of air-conditioned homes and buildings may reduce the average ability of air pollutants to reach residents for much of the day, which may diminish the overall population adverse health implications of outdoor air pollution in those cities versus cities without extensive air conditioning.
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As additional studies are conducted in multiethnic populations the adverse effects of population stratification are likely to arise [5], [6].
A total of 16 (28.5%) subjects in the randomized population experienced adverse events.
Rapid population growth, adverse effects of climate change and changes in biotypes of BPH exert pressure on increasing rice production.
Moreover, patients with cardiac disease may also be more vulnerable than the general population to adverse effects of transfusion (disturbed rheology [71] and coagulation [65], NISHOT [57], dysfunctional vasoregulation [72], circulatory overload, and so on).
We described the study population and adverse event proportions using descriptive statistics.
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