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The densely populated sequence was worthy of Robert Altman.
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Previously we have proposed that in wild-type SH3 domain at pH 2.0 and 4Ala mutant at pH 6.5 [11], the folding was trapped at the first stage in which no significant tertiary packing was in place but the non-native helical conformations are highly-populated over the whole sequence except for the N- and C-termini.
The developers' intention was to perform the destruction sequence away from populated locations.
By contrast, previously in the wild-type SH3 at pH 2.0 and 4Ala mutant at pH 6.5, the non-native helical conformations were found to be highly-populated over almost the whole sequence except for the N- and C-termini but in the meanwhile no long-range NOEs could be observed.
Of course, until a whole genome sequence and a densely populated genetic map become available, it is not possible to precisely define the ratio of genetic to physical distance across the genome of a species to which a GWAS is being conducted.
In a young cluster the main sequence will be well-populated, but in an old cluster the heavier stars will have evolved away from the main sequence.
Therefore, we categorized the population density as moderately populated ρ pop = 0 and densely populated ρ pop = 1.
Five populated clusters of MazF toxins were obtained and sequence analysis was used to identify an evolutionarily conserved toxin-binding hotspot for antitoxin/peptides.
Despite the biological importance of PPIs and the availability of high-throughput screening methods in recent years, experimentally-verified PPI networks remain sparsely populated, especially with respect to the amount of sequence data currently available.
With more sensitive sequencing methods becoming the norm, sparsely populated communities like those in the lung are easier to study.
The CATH database of domain structures has been used to explore the structural variation of homologous domains in 294 well populated domain structure superfamilies, each containing at least three sequence diverse relatives.
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