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We present p for trend, p for quadratic term, or p for cubic term, representing each category by its median value (median values of serum concentrations for individual POPs measures and median ranks for summary POPs measures).
We formed summary POPs measures by applying three rationales.
Previously, Govarts et al. (2012) identified 14 cohorts of mother child pairs with POPs measures from the Environmental Health Risks in European Birth Cohorts' (ENRIECO) inventory (http://www.enrieco.org/).
Based on previous findings, we also hypothesized that we would find stronger associations with summary POPs measures than with individual POPs and that these associations would be stronger among obese persons than among nonobese persons.
In this situation, a summary POPs measures formed by summing individual ranks of the POPs, for example, those 16 POPs with ORs of ≥ 1.5 in the second quartile in individual analyses, facilitates selecting a reference group with extremely low concentrations of those POPs that are relevant to a risk of type 2 diabetes.
In the absence of known biological mechanism(s) and demonstrated low-dose effects of POPs on type 2 diabetes, our grouping of individual POP analyses, coupled with the consistency of our results with previous findings for prevalent diabetes (Lee et al. 2006b, 2007c), can be justified to create summary POPs measures based on results of individual POP analyses.
Both standardization of summary POP measurements (TEQ versus measured values or sum of POPs functional subgroups) and adjustment for lipid levels are ongoing challenges that require consensus in order to facilitate data comparison and meta-analysis.
The piano part, though seemingly cool and reticent, included treacherous metrical juxtapositions; in one eye-popping measure near the end of the third movement, five-beat patterns in the right hand scuttled over groupings of three and four notes in the left.
POPs measured in 1987-88 (year 2) sera included 8 organochlorine (OC) pesticides, 22 polychlorinated biphenyls (PCBs), and 1 polybrominated biphenyl (PBB).
