Exact(4)
Modeling simultaneous variations in volume and lipid composition of maternal tissues and breast milk over time is critical in characterizing POP distribution and thus infant exposure.
However, studies of the heterogeneity of POP distribution across AT depots need to be confirmed because of the limited number of subjects that were studied (Ronn et al. 2011; Roos et al. 2012).
These studies should also account for heterogeneity of POP distribution that is dependent on variation both within and between the class of POPs as well as on their physiochemical properties.
Ample research points to adipose tissue being a central factor in POP toxicity, but significant knowledge gaps remain with regard to obesogens' mechanisms of action, POP distribution and dynamics in the body, and the molecular pathways disrupted by or involved in POP toxicity.
Similar(56)
The role of physiology in POP tissue distribution explores several aspects of lipid biochemistry and POP accumulation, including the concept that tissue differences in POP distributions often closely reflect differences in the lipid composition of tissues, rather than total lipids.
Table 3 shows POPs distribution of the study subjects.
Because lipophilic POPs distribution is solely driven by their solubility in lipids, infant blood and tissue lipid-adjusted concentrations at birth were equal to lipid-adjusted levels in maternal blood at the time of delivery.
The chapter describes the factors governing the bioavailability of POPs and the role of physiology in POP tissue distribution.
We first showed that the patterns of POP congeners distributions in the subcutaneous and visceral adipose tissue depots are extremely similar.
"I had bedbugs once," a young woman from the neighborhood told me, shaking her arms as if to fend off imaginary insects as she looked over at a picked-through heap of shirts and pants on the ground next to a "pop up" food distribution site where volunteers were cooking chicken".
BUCKy-pop uses a distribution of gene trees as input, which we approximate using bootstrap gene trees; thus, BUCKy-pop can only be run with a procedure analogous to All BS.
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