The human TGF-β1 transcript is inherently poorly translated, and translational activation has been documented in relation to several stimuli.
It was proposed that specific mRNAs that are poorly translated when translation initiation is low or normal become highly translated upon eIF2α dephosphorylation [22].
In this regard, rolA mRNA appears to be poorly translated in a wheat germ translation assay [ 18, 19].
Similar to the 5'terminal oligopyrimidine (5'TOP) genes, almost 90%% of these genes were poorly translated in RBS cells, but their translational efficiency improved dramatically with both 3 and 24 h of L-Leu supplementation (Fig. 2b).
Hence, changes in translational status are observed primarily for transcripts that are poorly translated in the control or show a big discrepancy between their transcriptional and translational regulation.
Inhibition of translation caused by alterations in the 5'ULR of poorly translated mRNA, such as MFA2 of yeast, has little effect on the decay rate of its mRNA [ 22].
11) The authors discuss qualitatively the observation that many abundant but poorly translated mRNAs are not detectable by proteomics, in contrast to well-translated messages.
The last one, I admit, may be poorly translated.
The girl started reading out bits of it, haltingly, as if from a poorly translated instruction manual.
Haven't we outgrown the decade(s) of making ourselves the butt of poorly translated Japanese manual jokes?
"For most voters, it resembles something written in Greek as poorly translated from the original Urdu," said William M. Lunch, a political science professor at Oregon State University.
